College football odds, picks, predictions, best bets for Week 4, 2022: Proven simulation likes USC, Texas

The Week 4 college football schedule could serve as a “prove-it” week for several programs that have gotten off to strong starts, as well as teams that have looked shaky but have an opportunity to show they can right the ship. Wake Forest is No. 21 in the AP Top 25 rankings and will see if its offense is for real against No. 5 Clemson, who visits as a 7-point favorite. Iowa State dropped 43 points on Ohio after slogging through a 10-7 win at Iowa in Week 2, and opens Big 12 play as a 3-point home favorite against No. 17 Baylor in the latest Week 4 college football odds listed on Caesars Sportsbook. .

Many teams have yet to challenge themselves in high-profile non-conference matchups, so figuring out how they stack up this week is key to coming out on the right side of your Week 4 college football bets. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the college picks the model is high on in Week 4: No. 22 Texas (-7) heads north to Lubbock and covers against Texas Tech at 3:30 pm ET on Saturday. Coach Steve Sarkisian confirmed this week that quarterback Quinn Ewers will be in uniform for this one just two weeks after injuring his SC joint against Alabama. The original prognosis was that he’d be out around six weeks.

Whether it is Ewers or experienced backup Hudson Card under center, the Longhorns should be in good shape. Running back Bijan Robinson is one of the nation’s best players at the position, and SportsLine’s model projects that he’ll run for more than 100 yards. The Longhorns cover 60% of the time, while the Over (61) is the recommended play on the total since that clears more than 60% of the time as well.

Another one of the model’s college football picks: No. 7 USC (-6) goes on the road and covers against Oregon State in a 9:30 pm ET matchup in Corvallis. USC’s offense is clicking on all cylinders already, scoring 40-plus points in all three of its games this season. The Trojans are led by sophomore quarterback Caleb Williams, who has completed 74.4% of his passes for 874 yards and eight touchdowns.

Oregon State’s defense has looked shaky at times early in the year, giving up 28 points to Montana State and 32 points to Fresno State. The Beavers are going to have trouble matching the Trojans blow for blow on Saturday night. SportsLine’s model is expecting another big day from Williams, as he is throwing for more than 320 yards and three touchdowns in the latest simulations.

Oregon State quarterback Chance Nolan is not having nearly as much success in the simulations, completing just 16 of 26 passes for less than 240 yards and an interception. The Trojans are one of the strongest picks of the week, covering the spread in more than 70% of simulations. See which other teams the model likes here.

How to make college football picks for Week 4

The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it says a Top 25 favorite will go down hard in one of the week’s biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,300 in profit over the past six-plus seasons, and find out.

College football odds for Week 4 (via Caesars)

See full Week 4 college football picks, odds, predictions here

Saturday, Sept. 24

Kent State at Georgia (-45, 62)

Maryland at Michigan (-17, 64.5)

Featured Game | Michigan Wolverines vs. Maryland Terrapins

Central Michigan at Penn State (-28, 63.5)

Featured Game | Penn State Nittany Lions vs. Central Michigan Chippewas

Duke at Kansas (-7, 65.5)

Featured Game | Kansas Jayhawks vs. Duke Blue Devils

Clemson at Wake Forest (+7, 55.5)

Featured Game | Wake Forest Demon Deacons vs. Clemson Tigers

Baylor at Iowa State (-2.5, 45.5)

Featured Game | Iowa State Cyclones vs. Baylor Bears

Florida at Tennessee (-10.5, 62.5)

Featured Game | Tennessee Volunteers vs. Florida Gators

Notre Dame at North Carolina (-1.5, 55)

Featured Game | North Carolina Tar Heels vs. Notre Dame Fighting Irish

Texas at Texas Tech (+7, 61)

Featured Game | Texas Tech Red Raiders vs. Texas Longhorns

Tulsa at Ole Miss (-21.5, 65.5)

Featured Game | Ole Miss Rebels vs. Tulsa Golden Hurricane

Oregon at Washington State (+6.5, 57.5)

Featured Game | Washington State Cougars vs. Oregon Ducks

Northern Illinois at Kentucky (-26.5, 53)

Featured Game | Kentucky Wildcats vs. Northern Illinois Huskies

Arkansas at Texas A&M (-2, 48.5)

Featured Game | Texas A&M Aggies vs. Arkansas Razorbacks

Wisconsin at Ohio State (-19, 57)

Featured Game | Ohio State Buckeyes vs. Wisconsin Badgers

Vanderbilt at Alabama (-40.5, 59)

Kansas State at Oklahoma (-12.5, 53)

Featured Game | Oklahoma Sooners vs. Kansas State Wildcats

USC at Oregon State (+6, 70.5)

Featured Game | Oregon State Beavers vs. USC Trojans

Utah at Arizona State (+15.5, 54)

Featured Game | Arizona State Sun Devils vs. Utah Utes

Stanford at Washington (-13.5, 63.5)

Featured Game | Washington Huskies vs. Stanford Cardinal

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